本文报道12例有多次输血史的重型地中海贫血患者经血清学、肝组织学和分子生物学检测证实患有由HCV引起的慢性肝炎,其中男8例,女4例,平均年龄20岁,平均输血量290单位。所有患者均用重组α-2b干扰素300万单位皮下注射,每周3次。初每周随访1次,后每月1次,3个月时评定疗效分级:转氨酶转为正常属CR,降低50％以上为PR者,继续用相同剂骨治疗:如转氨酶无变化或降 This article reports 12 cases of heavy thalassemia patients with multiple transfusion history confirmed by HCV serology, liver histology and molecular biology tests with chronic hepatitis, including 8 males and 4 females, mean age 20 years, The average blood transfusion 290 units. All patients were injected subcutaneously with 3 million recombinant interferon alpha-2b 3 times a week. At the beginning of every week, the patients were followed up once a week, once a month, and at 3 months, the therapeutic effect was graded: the transaminase was changed to normal CR and the reduction of PR was over 50%