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目的:研究核转录因子-κB(NF-κB)在人胸主动脉瘤(TAA)和腹主动脉瘤(AAA)中的表达及其意义。方法:收集TAA标本13例、AAA标本20例以及正常主动脉标本6例,用免疫组织化学法检测其中NF-κB的表达;并对其中的TAA标本8例、AAA标本10例及正常主动脉标本6例用Western blot法检测其中NF-κB的表达。结果:在免疫组化实验和Westernblot实验中,NF-κB在TAA组和AAA组中都呈现阳性表达,而在正常对照组中为阴性,TAA组和AAA组与正常对照组比较差异有统计学意义(P<0.05),TAA组与AAA组之间的表达差异无统计学意义(P>0.05)。结论:NF-κB与人TAA及AAA的发病存在着相关性。
Objective: To study the expression and significance of NF-κB in human thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA). Methods: Thirteen cases of TAA, 20 cases of AAA and 6 cases of normal aorta were collected. The expression of NF-κB was detected by immunohistochemistry. Among them, 8 cases of TAA, 10 cases of AAA and normal aorta Western blot was used to detect the expression of NF-κB in 6 specimens. Results: The expression of NF-κB in both TAA group and AAA group was positive in immunohistochemistry and Western blot, but negative in normal control group. There was significant difference between TAA group and AAA group and normal control group (P <0.05). There was no significant difference between TAA group and AAA group (P> 0.05). Conclusion: There is a correlation between NF-κB and human TAA and AAA.