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实验室研究表明,百日咳菌苗(PBV)能促进血清IgE抗体的产生。本研究通过检测婴儿接种DTP后产生的IgE抗体,首次获得了PBV接种可诱生百日咳抗原特异性IgE抗体的证据。对随机抽样的47名黑人和白人新生儿接种3针DTP,定期检测百日咳IgE抗体。使用敏感性极高的被动放射免疫吸附试验(PRIST)和放射变应原吸附试验(RAST)分别检查出生时的脐带血、3和12月龄血清中的IgE总量和对百日咳杆菌、牛奶、蛋清和屋尘螨抗原的特异性IgE。免疫用DTP中的
Laboratory studies have shown that pertussis vaccine (PBV) can promote serum IgE antibody production. In this study, we obtained the first evidence that PBV inoculation induced pertussis antigen-specific IgE antibodies by detecting the IgE antibodies produced after DTP inoculation. Forty-seven black and white newborns were randomized to receive 3-dose DTP and to regularly test for pertussis IgE antibodies. Uterus cord blood at birth, total IgE in serums at 3 and 12 months of age, and plasma levels of Bordetella pertussis, milk, Specific IgE for egg white and house dust mite antigens. Immunization with DTP