本文报告应用结核菌苗作肿瘤灶内注射进行免疫疗法的25例患者中,12％(有多处转移的黑色素瘤■例,转移性皮下鳞癌1例)发生了肉芽肿性肝炎。1例于注射后两周出现寒战高热,肝脾肿大;另2例仅有发热或伴有恶心呕吐、全身不适。肝功能均不正常,肝活检证明均系多灶性非干酪性肉芽肿,涂片及培养 This article reports that 25% of 25 patients who received tuberculosis vaccine for intracranial injection for immunotherapy had granulomatous hepatitis in 12% (multiple metastases of melanoma, and metastatic subcutaneous squamous cell carcinoma). 1 case appeared two weeks after injection chills fever, hepatosplenomegaly; the other two cases only fever or nausea and vomiting, general malaise. Liver function are not normal, liver biopsy proved to be multifocal non-cheese granuloma, smear and culture