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本文对198例成人肾素活性(PRA)和血管紧张素Ⅱ(AⅡ)进行测定,其中正常人50例,急性病毒性肝炎38例,原发性肝细胞癌14例,肝硬化代偿期者22例,肝硬化失代偿期者69例.测定结果:肝硬化失代偿期组的PRA和AⅡ高于其他组,提示该期患者肾素——血管紧张素系统被激活.用心得安治疗20例肝硬化失代偿期伴腹水的患者,给予口服20～60mg/日一个月,有效率为65%,治疗结果提示心得安可作为一种非利尿疗法治疗肝硬化腹水.本组未见明显副反应.
In this paper, 198 cases of adult renin activity (PRA) and angiotensin Ⅱ (A Ⅱ) were measured, including 50 cases of normal, 38 cases of acute viral hepatitis, 14 cases of primary hepatocellular carcinoma, compensated cirrhosis 22 cases, 69 cases of decompensated liver cirrhosis.Results: The patients with decompensated liver cirrhosis PRA and A Ⅱ higher than other groups, suggesting that patients with renin - angiotensin system is activated. Treatment of 20 patients with decompensated liver cirrhosis with ascites, given orally 20 ~ 60mg / day a month, the effective rate was 65%, the results suggest that the experience may be safe as a non-diuretic treatment of cirrhosis and ascites. See obvious side effects.