利福平,又名甲哌力复霉素,是一种人工合成的广谱抗菌素,对革兰氏阳性和阴性细菌以及病毒均有抑制作用。本药口服后,吸收迅速,并很快分布于组织中,在肺、肾、肝、胆汁中的浓度均比血浓度高。其分子量小,穿透力强,能杀灭细胞内外的结核杆菌,在酸性和硷性环境中不丧失其活性,对代谢旺盛的菌群以及间歇生长的结核杆菌均有杀灭作用,对于一线抗结核药耐药的结核杆菌也有抑制或杀灭作用。利福平在试管内对结核杆菌的抑菌浓度为 Rifampicin, also known as mequindox, is a synthetic broad-spectrum antibiotic that inhibits Gram-positive and -negative bacteria and viruses. After oral administration, the rapid absorption, and quickly distributed in the tissue, the concentration in the lung, kidney, liver, bile than blood concentration. The molecular weight of small, strong penetration, can kill cells inside and outside of Mycobacterium tuberculosis in acidic and alkaline environment does not lose its activity on the metabolic flora and intermittent growth of Mycobacterium tuberculosis are killing effect for the first-line Anti-TB drug-resistant Mycobacterium tuberculosis also inhibit or kill. Rifampicin in vitro inhibition of Mycobacterium tuberculosis concentration