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目的 了解50岁及以上梅毒患者临床特征,探讨其相关危险因素.方法 回顾性分析2015年1月-2017年1月本院确诊的176例年龄≥50岁梅毒患者的临床资料,并将本院230例非梅毒患者列为对照组,分别进行问卷调查,对梅毒感染相关危险因素进行单因素和多因素Logistic回归分析.结果 176例梅毒患者中,男102例(57.95％),女74例(42.04％).以50 ～ 69岁最多(136例,占77.27％);初中及以下文化程度140例,占79.55％;职业分布以农民/民工(42例,占23.86％)和工人/退休工人(61例,占34.66％)为主.潜伏梅毒143例,占81.25％,且103例(58.52％)是因术前检查及住院筛查而首次就诊.Logistic多因素分析显示:非婚性行为、安全套使用情况、对嫖娼的态度及梅毒知晓情况是梅毒感染的主要危险因素.结论 加强婚内性道德、性观念的健康教育,降低非婚性行为发生率,推广安全套使用,提高该人群梅毒知识知晓率,是目前预防和控制50岁及以上人群梅毒感染的重要措施.“,”Objective To understand the clinical characteristics of syphilis patients exceeded age 50,and to analyse the related risk factors.Methods The retrospective analysis was conducted based on the clinical data of 176 syphilis patients diagnosed in our hospital from January 2015 to January 2017,and 230 patients without syphilis were classified into the control group.The questionnaire survey was carried out,and the related risk factors of syphilis infection were analyzed by single factor and multivariate Logistic regression.Results Among the 176 patients with syphilis,102 were the males (57.95％) and 74 were the females (42.04％).The number of the age between 50 and 69 were the most(136 cases,77.27％).There were 140 cases in middle school and below,accounting for 79.55％.Occupations were mainly farmers/migrant workers (42 cases,23.86％) and workers/retired workers (61 cases,34.66％).There were 143 cases of latent syphilis,accounting for 81.25％,and 103 cases (58.52％) were treated for the first time by preoperative examination and hospital screening.Multivariate analysis showed that the non-marital sex,condom use,attitudes towards whoring and awareness of syphilis were the major risking factors for syphilis infection in people aged more than 50.Conclusion Strengthen the marital morality and sexual education,reduce the incidence of Non-marital sex,to promote the use of condoms,improve the awareness rate of syphilis knowledge,which is currently the important measures for the prevention and control of syphilis infection in people aged 50 years and above.