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目的探讨多索茶碱治疗支气管哮喘的疗效及对肺功能的影响。方法将收治的94例支气管哮喘患者完全随机分为观察组和对照组,各47例,分别在常规治疗的基础上加用多索茶碱和氨茶碱静脉滴注治疗7 d,比较两组患者治疗前后肺功能指标的变化、不良反应发生情况,并评价患者临床疗效。结果两组患者治疗后FEV1、FVC、FEV1/FVC及PEF均较治疗前明显改善(P<0.01),且观察组患者肺功能改善明显优于对照组(P<0.01);观察组患者治疗总有效率为85.1%,明显高于对照组的63.8%(P<0.05),不良反应发生率与对照组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论多索茶碱可有效改善支气管哮喘患者的肺功能,治疗效果良好,具有较高的安全性。
Objective To investigate the therapeutic effect of doxofylline on bronchial asthma and its effect on pulmonary function. Methods A total of 94 patients with bronchial asthma were randomly divided into observation group and control group, 47 cases in each group. On the basis of routine treatment, Doxofylline and aminophylline were given intravenously for 7 days. Before and after treatment of patients with changes in lung function indicators, the occurrence of adverse reactions, and evaluate the clinical efficacy of patients. Results The FEV1, FVC, FEV1 / FVC and PEF in both groups were significantly improved after treatment (P <0.01), and the improvement of pulmonary function in observation group was better than that in control group (P <0.01) The effective rate was 85.1%, which was significantly higher than that of the control group (63.8%, P <0.05). The incidence of adverse reactions was not significantly different from that of the control group (P> 0.05). Conclusion Doxofylline can effectively improve the lung function of patients with bronchial asthma, the treatment effect is good, with high safety.