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目的观察小剂量胺碘酮治疗器质性心脏病恶性室性心律失常的疗效。方法治疗组75例采用小剂量胺碘酮治疗,对照组70例采用常规剂量美西律治疗,观察两组治疗前后的临床症状、恶性室性心律失常(VT/VF)发作频率、持续时间、心脏性猝死发生率以及心功能改善等情况。结果小剂量胺碘酮对改善器质性心脏病VT/VF患者症状,减少VT/VF发作频率和持续时间,降低猝死风险,改善心功能等疗效确切。结论小剂量胺碘酮对治疗器质性心脏病VT/VF和预防VT/VF复发是安全有效的,患者耐受性良好,适合基层医院广泛使用。
Objective To observe the effect of low dose amiodarone on malignant ventricular arrhythmia caused by organic heart disease. Methods 75 cases were treated with low dose amiodarone in treatment group and 70 cases in control group were treated with routine dose of mexiletine. The clinical symptoms, frequency and duration of malignant ventricular arrhythmia (VT / VF) The incidence of sudden cardiac death and cardiac function improvement and so on. Results Low dose amiodarone was effective in improving the symptoms of VT / VF patients with structural heart disease, reducing the frequency and duration of VT / VF attacks, reducing the risk of sudden death and improving cardiac function. Conclusion Low-dose amiodarone is safe and effective for the treatment of VT / VF and prevention of VT / VF recurrence. Patients with low-dose amiodarone are well tolerated and are suitable for use in primary hospitals.