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目的探讨人表皮生长因子受体(HER)家族中的HER2、HER3的表达对胃癌患者预后的影响。方法采用免疫组化对67例经手术切除的胃癌组织进行检测,将检测结果与患者的临床特征进行相关性分析。结果 21例(31.3%)患者HER2高表达,38例(56.7%)患者HER3高表达,18例(26.9%)患者有HER2、HER3双重高表达。HER2高表达与患者的临床特征无相关性,HER3高表达仅与肿瘤位于近段有相关性(P<0.05),HER2表达与HER3表达有相关性(P<0.05)。HER2和HER3高表达与患者的生存无相关性。结论 HER2和HER3高表达在胃癌中发生率较高,但它们的表达与患者的预后无相关性。
Objective To investigate the effect of HER2 and HER3 expression in human epidermal growth factor receptor (HER) family on the prognosis of patients with gastric cancer. Methods Immunohistochemistry was used to detect 67 cases of surgically resected gastric cancer tissues. The correlation between the results and the clinical features of the patients was analyzed. Results HER2 was highly expressed in 21 patients (31.3%), HER3 was highly expressed in 38 patients (56.7%), and HER2 and HER3 were highly expressed in 18 patients (26.9%). The high expression of HER2 had no correlation with the clinical features of patients. The high expression of HER3 was only related to the tumor located in the proximal segment (P <0.05). The expression of HER2 was correlated with HER3 expression (P <0.05). There was no correlation between HER2 and HER3 overexpression and patient’s survival. Conclusion The high expression of HER2 and HER3 in gastric cancer is higher, but their expression has no correlation with the prognosis of patients.