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早在1863年Virchow等就发现了肿瘤部位有炎性细胞浸润，以后人们逐渐认识到肿瘤部位的炎性细胞浸润反映了机体对肿瘤的免疫效应，且与预后有关。到1986年Roseberg等成功的从肿瘤组织中分离出浸润淋巴细胞，并用11。－2扩增后回输给荷瘤小鼠，使肿瘤消退，引起人们对TIL与细胞因
As early as 1863, Virchow et al. discovered inflammatory cell infiltration at the tumor site. Later, people gradually realized that inflammatory cell infiltration at the tumor site reflects the immune effect of the body on the tumor and is related to the prognosis. By 1986 Roseberg et al successfully isolated infiltrating lymphocytes from tumor tissue and used 11 . -2 After amplification, return to tumor-bearing mice to regress the tumor and cause people to have TIL and cytology.