论文部分内容阅读
目的探讨依达拉奉联合黄芪在急性一氧化碳中毒(ACMP)治疗中的作用。方法将60例ACMP患者随机分为治疗组及对照组各30例。对照组给予高压氧等常规治疗,治疗组在常规治疗基础上加用依达拉奉和黄芪,疗程14d。于治疗前后检测血清超氧化物歧化酶(SOD)活性、血清丙二醛(MDA)及谷氨酸(GLU)水平,2个月时对患者进行随访,比较两组一氧化碳中毒迟发型脑病(DEACMP)的发生率。结果治疗组血清SOD活性显著提高,MDA水平明显降低,GLU水平降低(P<0.05);治疗组DEACMP发病率低于对照组(P<0.05)。结论依达拉奉联合黄芪通过减低ACMP患者血清中自由基和兴奋性氨基酸的含量,保护神经功能,改善预后。
Objective To investigate the role of edaravone and astragalus in the treatment of acute carbon monoxide poisoning (ACMP). Methods 60 cases of ACMP were randomly divided into treatment group and control group of 30 cases. The control group was given conventional therapy such as hyperbaric oxygen. The treatment group added edaravone and astragalus on the basis of routine treatment for 14 days. Serum levels of superoxide dismutase (SOD), serum malondialdehyde (MDA) and glutamate (GLU) were measured before and after treatment. The patients were followed up at 2 months. Two groups of patients with delayed type encephalopathy after carbon monoxide poisoning ) Incidence. Results Serum SOD activity was significantly increased, MDA level was significantly decreased and GLU level was decreased in treatment group (P <0.05). The incidence of DEACMP in treatment group was lower than that in control group (P <0.05). Conclusion Edaravone combined with Astragalus can decrease the content of free radicals and excitatory amino acids in serum of ACMP patients and protect the neurological function and prognosis.