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目的观察甲硫胺酸维生素B1+熊去氧胆酸治疗妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy,ICP)的临床效果。方法奉节县妇幼保健院妇产科入院治疗的ICP患者120例。随机分为两组,观察组使用甲硫胺酸维生素B1+熊去氧胆酸治疗;对照组使用熊去氧胆酸治疗。观察两组患者CG、ALT、AST、TBiLi、DbiLi值的变化。结果甲硫胺酸维生素B1+熊去氧胆酸联合治疗ICP,能明显降低CG、ALT、AST、TBiLi、DbiLi值,缓解临床症状。结论甲硫胺酸维生素B1治疗ICP疗效明显。
Objective To observe the clinical effect of methionine vitamin B1 + ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy (ICP). Methods A total of 120 ICP patients were admitted to obstetrics and gynecology hospital of Fengjie County Maternal and Child Health Hospital. Randomly divided into two groups, the observation group using methionine vitamin B1 + ursodeoxycholic acid treatment; control group using ursodeoxycholic acid treatment. The changes of CG, ALT, AST, TBiLi and DbiLi in two groups were observed. Results Methionine vitamin B1 + ursodeoxycholic acid combined treatment of ICP, can significantly reduce the CG, ALT, AST, TBiLi, DbiLi value, relieve clinical symptoms. Conclusion Methionine vitamin B1 treatment of ICP effect.