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目的:探讨血浆脑钠肽(BNP)水平在左向右分流型先天性心脏病患儿心功能评级中的应用价值。方法:选取中山市博爱医院、大涌医院2017年4月至2019年8月收治的左向右分流型先天性心脏病患儿60例(右心型和左心型各30例)为研究对象，其中右心型先天性心脏病患儿为研究1组，左心型先天性心脏病患儿为研究2组，另选取同时间段常规体检的健康儿童30例为对照组。三组均进行血浆BNP浓度测定和超声心动图测量，比较三组血浆BNP浓度水平、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、右室舒张末期内径(RVEDD)、肺循环血流量/体循环血流量比值(Qp/Qs)及左室心肌做功(Tei)指数。结果:研究1组LVEF、RVEDD与对照组比较，差异均无统计学意义(均n P>0.05)；研究1组的LVEDD[(45.40±7.48)mm]、Qp/Qs[(1.80±0.25)]、左室Tei指数[(0.35±0.14)]、BNP[(64.33±22.18)ng/L]均明显高于对照组[(34.33±4.93)mm、(0.95±0.11)、(0.28±0.05)、(33.66±10.80)ng/L]，差异均有统计学意义(n t＝6.77、17.05、2.56、6.81，均n P0.05)；研究2组的LVEDD[(45.39±7.52)mm]、Qp/Qs[(1.78±0.25)]、左室Tei指数[(0.35±0.14)]、BNP[(64.30±22.21)ng/L]均明显高于对照组[(34.33±4.93)mm、(0.95±0.11)、(0.28±0.05)、(33.66±10.80)ng/L]，差异有统计学意义(n t＝6.74、16.64、2.58、6.80，均n P<0.05)；研究1组的BNP水平与RVEDD、Qp/Qs、左室Tei指数均呈正相关(n r＝0.629、0.719、0.651，均n P<0.05)；研究2组的BNP水平与RVEDD、Qp/Qs、左室Tei指数均呈正相关(n r＝0.539、0.792、0.748，均n P0.05)。研究1组手术后BNP[(44.05±12.41)ng/L]、LVEDD[(43.48±4.45)mm]、Qp/Qs[(1.03±0.06)]、左室Tei指数[(0.31±0.10)]均低于该组手术前，差异均有统计学意义(n t＝5.23、2.94、18.20、3.34，均n P<0.05)；研究2组手术后BNP[(40.96±14.30)ng/L]、LVEDD[(22.23±3.65)mm]、Qp/Qs[(1.05±0.11)]、左室Tei指数[(0.31±0.05)]均低于该组手术前，差异均有统计学意义(n t＝3.86、3.08、14.73、4.26，均n P0.05). The LVEDD[(45.40±7.48)mm], Qp/Qs (1.80±0.25), left ventricular Tei index(0.35±0.14), BNP[(64.33±22.18)ng/L] in the study group 1 were significantly higher than those in the control group[(34.33±4.93)mm, (0.95±0.11), (0.28±0.05), (33.66±10.80)ng/L], the differences were statistically significant (n t=6.77, 17.05, 2.56, 6.81, all n P0.05). The LVEDD[(45.39±7.52)mm], Qp/Qs (1.78±0.25), left ventricular Tei index(0.35±0.14) and BNP[(64.30±22.21)ng/L] in the study group 2 were significantly higher than those in the control group[(34.33±4.93)mm, (0.95±0.11), (0.28±0.05), (33.66±10.80)ng/L], the differences were statistically significant(n t=6.74, 16.64, 2.58, 6.80, all n P<0.05). The BNP level in study group 1 was positively correlated with RVEDD, Qp/Qs and left ventricular Tei index(n r=0.629, 0.719, 0.651, all n P<0.05). The BNP level in the study group 2 was positively correlated with RVEDD, Qp/Qs and left ventricular Tei index(n r=0.539, 0.792, 0.748, all n P0.05). After operation, the BNP[(44.05±12.41)ng/L], LVEDD[(43.48±4.45)mm], Qp/Qs(1.03±0.06) and left ventricular Tei index(0.31±0.10) in the study group 1 were lower than those before operation, and the differences were statistically significant (n t=5.23, 2.94, 18.20, 3.34, all n P<0.05). After operation, the BNP[(40.96±14.30)ng/L], LVEDD[(22.23±3.65)mm], Qp/Qs(1.05±0.11) and left ventricular Tei index(0.31±0.05) in the study group 2 were lower than those before operation, and the differences were statistically significant(n t=3.86, 3.08, 14.73, 4.26, all n P<0.05).n Conclusion:The application of plasma BNP level detection in left-to-right shunt congenital heart disease has definite effect and certain application value.