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目的:探讨氟[18F] 氟代脱氧葡萄糖(18F FDG)双探头符合线路单光子发射型计算机断层(SPECT)双时相显像鉴别病变性质的临床应用价值。方法: 30例病变性质不明的患者进行18F FDG符合线路SPECT双时相显像,早期显像在注射18FDG后1h进行,延迟显像分为2组,一组时间间隔为3. 5h,另一组时间间隔为4. 5h。结果:30例患者(1例患者行2次双时相显像)共检出48个病灶,其中恶性病变30个,良性病变18个,均经病理活检证实或临床随访确诊。用定性法分析,双时相显像的灵敏度96. 7%,特异性83. 3%,准确率91. 7%,阳性预测值90. 6%,阴性预测值93. 8%。符合线路SPECT早期显像和CT检查的灵敏度、特异性、准确率、阳性预测值、阴性预测值分别为93. 3%, 72. 2%, 85. 4%, 84. 8%, 86. 7%与76. 9%, 57. 1%, 70. 0%, 76. 9%, 57. 1%。所有恶性病变(除1例假阴性病变外)延迟显像T/NT均明显升高(t=-3. 071,P<0. 01),而良性病变延迟显像与早期显像T/NT差异无统计学意义(t=0. 398,P=0. 695)。结论: 18F FDG符合线路SPECT双时相显像有利于良、恶性病变鉴别,并有助于提高病变诊断的特异性及准确率。
Objective: To investigate the clinical value of fluorodeoxyglucose (18F) fluorodeoxyglucose (18F FDG) dual-head coincidence single photon emission computed tomography (SPECT) dual-phase imaging in differentiating lesions. Methods: Thirty patients with unidentified lesions underwent 18F FDG coincidence SPECT bi-phase imaging. Early imaging was performed at 1 h after injection of 18FDG. Delayed imaging was divided into two groups with one interval of 3.5 h and the other one Group time interval 4. 5h. Results: Totally 48 lesions were detected in 30 patients (two bi-phase images in one patient), including 30 malignant lesions and 18 benign lesions, all confirmed by pathological biopsy or clinical follow-up. 8%. With qualitative analysis, double-phase imaging sensitivity 96.7%, specificity 83.3%, accuracy 91.7%, positive predictive value 90.6%, negative predictive value 93.8%. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of coincidence line SPECT imaging and CT examination were 93.3%, 72.2%, 85.4%, 84.8%, 86.7 % And 76.9%, 57.1%, 70. 0%, 76.9%, 57.1%. All of the malignant lesions (except one case of false-negative lesions) showed a significant increase in delayed imaging (T = -3.071, P <0.01), but delayed imaging of benign lesions and early imaging T / NT differences No statistical significance (t = 0.398, P = 0. 695). Conclusion: 18F FDG coincidence SPECT bi-phase imaging is good for the identification of benign and malignant lesions, and help to improve the specificity and accuracy of the diagnosis of lesions.