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目的:观察三乙醇胺乳膏在预防乳腺癌保留乳房术后同时推量调强放疗患者急性放射性皮炎中的作用。方法:选取101例2003-01-2010-03收治的早期乳腺癌保留乳房术后患者,分为预防组(52例)和对照组(49例)。预防组从放疗第1天预防性应用三乙醇胺乳膏涂抹照射野皮肤并>1cm的范围;对照组采用常规皮肤护理。结果:预防组Ⅰ、Ⅱ和Ⅲ度急性放射性皮炎的发生率分别为90.4%(47/52)、7.7%(4/52)和1.9%(1/52),对照组分别为69.4%(34/49)、24.5%(12/49)和6.1%(3/49),P=0.030。预防组≥Ⅱ度急性放射性皮炎的发生时间为21～36d,中位时间28d;对照组为14～35d,中位时间17d,P=0.006。放疗中断预防组2例,对照组8例,P=0.047。结论:三乙醇胺乳膏对早期乳腺癌保留乳房术后同时推量调强放疗所致的急性放射性皮炎有较好的预防效果,减轻了皮肤的急性放射性损伤,保障放疗计划顺利实施。
OBJECTIVE: To observe the effect of triethanolamine cream on the prevention of acute radiation dermatitis in patients with conserving mammary cancer after breast enlargement. Methods: A total of 101 patients with breast cancer who underwent breast conserving surgery from January 2003 to October 2010 were selected and divided into prevention group (n = 52) and control group (n = 49). The prophylactic group applied the prophylactic triethanolamine cream on day 1 of radiotherapy to the range of> 1 cm and the control group received conventional skin care. Results: The incidences of acute radiation dermatitis of grade Ⅰ, Ⅱ and Ⅲ in prevention group were 90.4% (47/52), 7.7% (4/52) and 1.9% (1/52) respectively, while those in control group were 69.4% (34/34) / 49), 24.5% (12/49) and 6.1% (3/49), P = 0.030. The incidence of acute radiodermatitis with ≥ Ⅱ degree in prevention group was 21-36 days with a median time of 28 days. The control group was 14-35 days with a median time of 17 days (P = 0.006). Radiation interruption prevention group 2 cases, control group 8 cases, P = 0.047. CONCLUSION: Triethanolamine cream has a good preventive effect on acute radiation dermatitis caused by breast enlargement and radiotherapy after breast-conserving surgery in early breast cancer, alleviating the acute radioactive injury of the skin and ensuring the smooth implementation of radiotherapy.