通常药物反应以皮疹表现为多见,同时发生内脏损害者较少见,尤其是变应性血管炎型药物反应更少见。笔者最近见到1例,现报告如下: 患者男性,62岁,干部。于1991年6月21日,因全身发生大小不等的出血性瘀斑,伴关节酸痛,来我院就医。患者因肛周脓肿,接受庆大霉素8万单位肌注一次,4小时后,口腔粘膜起水疱,糜烂,流血性分泌物。面部、四肢、躯干出现大小不等紫红色瘀斑及隆起皮肤小丘疹,伴有全身关节酸痛,双上肢有麻木感。患者4个月前,曾因白内障手术,在外院住院治疗,术后肌注庆大霉素8万单位每日2次。用药当天下午发生与本次相同症状,由于血小板减少至 2万/立方毫米,曾考虑“血液病”,经用激素治疗3周后好转。出院时,曾做血、尿常规,血小板检查皆正常。既往史:患高血压、糖尿病,对磺胺药过敏。无 Drug reactions usually rash performance is more common, while visceral lesions occur less common, especially allergic vasculitis type drug reactions are more uncommon. I recently saw a case, are as follows: The patient male, 62 years old, cadres. On June 21, 1991, due to systemic hemorrhagic ecchymosis ranging from size, with joint pain, come to our hospital for treatment. Patient perianal abscess, gentamicin 80,000 units intramuscular injection once, 4 hours later, the oral mucosa blisters, erosion, bleeding secretions. Facial, limbs, trunk appear ranging from purple petechiae and raised skin papules, accompanied by systemic soreness, numbness in both upper extremities. Patients 4 months ago, had cataract surgery, hospitalized outside the hospital, intramuscular injection of gentamicin 80,000 units 2 times a day. The same day afternoon medication and this same symptom, due to thrombocytopenia to 20,000 / cubic mm, had considered “blood disease”, after 3 weeks of treatment with hormone improved. Discharged, had done blood, urine, platelet tests are normal. Past history: suffering from high blood pressure, diabetes, allergy to sulfa drugs. no