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目的:了解氨酚羟考酮片用于阿片类药物辅助治疗的疗效及不良反应。方法:采用随机对照试验,选择中、重度癌痛患者应用阿片类药物未控或耐受的患者共66例,其中试验组32例,给予氨酚羟考酮片每次1片,q6h,疗程1周;对照组34例给予阿片类药物加量30%～50%。结果:氨酚羟考酮对阿片类药物疼痛未控或耐受的患者总有效率可达100%,不良反应发生率低。阿片类药物加量组有效率97.1%,两组间未见统计学差异。结论:氨酚羟考酮用于阿片类药物辅助镇痛疗效好,不良反应低并且可以耐受。
Objective: To understand the efficacy and side effects of oxycodone-containing tablets for opioid adjuvant therapy. Methods: A randomized controlled trial was conducted to select 66 cases of opioid uncontrolled or tolerated patients with moderate and severe cancer pain. Among them, 32 cases in the experimental group were given 1 tablet of paracetamol oxycodone every q6h, 1 week; the control group 34 patients given opioids plus 30% to 50%. Results: The total effective rate of oxycodone in patients with uncontrolled or refractory opioids was 100%, and the incidence of adverse reactions was low. Opioid dosage group 97.1% efficiency, no significant difference between the two groups. Conclusion: Oxycodone is effective in opioid analgesic therapy with low adverse reactions and can be tolerated.