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目的 研究肝移植术后细菌感染的流行病学规律。方法 回顾性分析 175例病人 180次原位肝移植术后细菌学资料。结果 肝移植术后感染率为 6 2 8% ( 113/180 ) ,平均感染时间为术后第 9天 ;共分离出菌株 2 84株 ,其中革兰阴性 (G-)杆菌占 5 4 6 % ( 15 5 /2 84) ;最常见的G-杆菌为铜绿假单胞菌 ,最常见的革兰阳性 (G+)球菌为粪肠球菌。易感器官依次为呼吸道、腹腔和胆道 ,感染率分别为 37 3 % ( 10 6 /2 84)、31 0 % ( 88/2 84)、2 1 1%( 6 0 /2 84)。结论 肝移植术后细菌感染率高 ,并以高度耐药菌为主 ,肝移植术后细菌感染部位与时间及菌群间有明显相关关系。
Objective To study the epidemiology of bacterial infection after liver transplantation. Methods A retrospective analysis of 175 cases of 180 patients after orthotopic liver transplantation bacteriological data. Results The infection rate after liver transplantation was 62.8% (113/180) and the average infection time was 9 days after operation. A total of 2 84 isolates were isolated, of which Gram-negative bacilli accounted for 54 46% (15 5/2 84). The most common G-bacilli were Pseudomonas aeruginosa and the most common Gram-positive (G +) coccus was Enterococcus faecalis. Susceptible organs followed by respiratory tract, abdominal cavity and biliary tract, the infection rates were 37 3% (106/284), 31 0% (88/2 84) and 21 1% (60/284) respectively. Conclusion The rate of bacterial infection after liver transplantation is high, and the majority are highly resistant bacteria. The site of bacterial infection after liver transplantation has obvious correlation with time and flora.