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目的:研究肺炎老龄大鼠的病理生理特点及中药毒素清对其作用。方法:复制大肠杆菌肺炎模型,分为模型组,毒素清高、低剂量组及氟哌酸组,同时设老龄对照组,共给药6天。观察肺脏组织病理改变,肺泡灌洗液中性粒细胞计数和外周血白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子(TNF)含量。结果:老龄模型组大鼠肺组织损伤明显,肺泡灌洗液白细胞和中性粒细胞计数高于老龄对照组,IL-8、IL-6、TNF 含量增高较老龄对照组显著。与老龄模型组比较,毒素清高剂量组白细胞和中性粒细胞计数降低,用药各组 IL-8、IL-6及 TNF 含量降低,其中高剂量组 IL-8及 TNF 含量低于低剂量组和氟哌酸组。结论:细胞因子紊乱参与老龄大鼠肺炎的病理生理过程,毒素清对其有明显的调节作用,这可能是该方治疗老年人肺炎的机制之一。
Objective: To study the pathophysiological characteristics of old pneumonia rats and the effect of Chinese herbal medicine toxin. METHODS: The E. coli pneumonia model was duplicated and divided into model group, toxin-clearing high-dose group, low-dose group and norfloxacin group, and aged control group was given for 6 days. Observe the pathological changes of the lung, neutrophil count in the bronchoalveolar lavage fluid and peripheral blood IL-6, IL-8 and TNF. Results: The lung tissue of old model rats was significantly damaged. The leukocyte and neutrophil counts in bronchoalveolar lavage fluid were higher than those in the old age control group. The levels of IL-8, IL-6 and TNF were significantly higher in the old model group than in the old control group. Compared with the aged model group, the leukocyte and neutrophil counts in the high-dose Toxin-purifying group decreased, and the levels of IL-8, IL-6, and TNF in the treated group decreased, and the levels of IL-8 and TNF in the high-dose group were lower than those in the low-dose group. Norfloxacin group. Conclusion: Cytokine disorder is involved in the pathophysiological process of pneumonia in aged rats, and toxin-clearing can obviously regulate it. This may be one of the mechanisms for the treatment of pneumonia in the elderly.