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以两种不同食谱诱发豚鼠生成胆色素结石进行随机对照研究，两组动物胆石形成率分别为８０．００％和４６．６７％（Ｐ＞０．０５），死亡率分别为Ｏ％和６０．００％（Ｐ＜０．０１）．结果提示，低蛋白、低维生素Ｃ饮食对豚鼠ＰＳ的形成虽起一定作用，但过低则会引起豚鼠死亡，而胆酸、胆固醇、猪油等可能是通过引起肝脏对胆红素等代谢紊乱而促进ＰＳ的形成．
The gallstone formation rate of guinea pigs was 80.00% and 46.67% (P> 0.05). The mortality rate was 0% and 60% respectively. 00% (P <0.01). The results suggest that low protein and low vitamin C diet may play a role in the formation of PS in guinea pigs, but too low will cause death in guinea pigs, while cholic acid, cholesterol and lard may cause metabolic disorders such as bilirubin in the liver And promote the formation of PS.