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目的探讨前白蛋白(PAB)、a1;-酸性糖蛋白(AAG)、a1-抗胰蛋白酶(AAT)在肝脏疾病中的临床意义.方法以散射比浊法测定132例各种类型肝脏疾病病人血清中的PAB、AAG.AAT值.结果PAB在急性肝炎(AH)、慢性肝炎(CH)、肝硬化(LC).重症肝炎(FVH)、肝癌(HCC)中的测定结果分别为:14.77.8,12.25.4,8.63.8,5.84.3,9.24.2(mg/dl),明显低于对照组(P＜0.01)AAG在AH、CH.LC.FVH、HCC测定值分别为80.226.2,42.020.0,41.023.2,25.813.6,102.048.0(ml/d10),其中AH组和HCC组明显高于对照组(P＜0.01),FVH组明显低于对照组(P＜0.01);AAT在AH、CH、LC、FVH、HCC测定值分别为18339,17843,15162,15252,22672(ml/dl),其中HCC组明显高于对照组(P＜0.01).结论PAN是反应早期肝脏功能损害的灵敏指标.PAB、AAG、AAT的检测对肝脏疾病的临床诊断有价值.“,”Objective To evaluate the clinical singnificance of measurement of sersum prealbundn(PAB),a1-acid glycoprotein(AAG),a1-antitrypsi(AAT) in patients with liver diseases.Methods Rate nephelometry was empolyed to measure the concentration of serum PAB,AAG and AAT in 132 patients with various liver diseases.Results The concentrations of serum PAB in patients with acute hepatitis(AH),chronic hepatitis(CH),liver cirrhosis(LC),falndnant viral hepatitis(FVH),and hepatocellular carcinoma(HCC) were 14.7 7.8,12.2 5.4,8.6 3.8,5.8 4.3 and 9.2 4.2(mg/dl)respectively;signiificantly lower than that in control group (P<0.01).The levels of serum AAG in patients with AH,CH,LC,FVH and HCC were 80.2 26.2,42.0 20.0,41.0 23.2,25.8 13.6 and 102.O 48.0 (mg/dl),respctively.The concentrations of AAC in patients with AH,and HCC were higher (P<0.01),while in patients with FVH was lower than that in control group (P<0.01).The levels of AAT in patients with AH,CH,LC,FVH,HCC were 183 39,178 43,151 62,152 52 and 226 72 (mg/dl)respectively.The level of serum AAT in patients with HCC was dramatically higher than that in control group(P<0.01).Conclusion It is useful t measure serum concentrations of PAB is a sensitive indicater reflecting hepatic functional damage in the early stage.Detection of PAB,AAG,and AAT is valuable in clinical diagnosis of liver diseases.