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目的 了解我省由两个不同社区 5岁以下婴幼儿细菌性痢疾患儿检出痢疾菌的耐药情况 ,探索相同血清型菌株耐药模式与病例间的流行病学关联。方法 美国疾病预防控制中心和WHO非洲区合作编写的“痢疾和霍乱流行的实验室诊断方法”中介绍的琼脂平板扩散法和美国临床实验室标准委员会推荐标准。结果 两市痢疾菌株的耐药率除萘啶酸外 (P <0 .0 5 ) ,其它 6种抗生素耐药率均无显著性差异 (均P >0 .0 5 )。结论 不同社区相同血清型的痢疾菌株除宋内氏菌外 ,均具有两种以上的耐药模式。耐药模式可以弥补单依血清型探索病例间的流行病学关联之不足。
Objective To understand the drug resistance of dysentery bacteria detected in children with bacillary dysentery in two different communities in two different communities in our province and to explore the epidemiological relationship between the drug resistance patterns of the same serotype strains and the cases. Methods The agar plate diffusion method and the American Society of Clinical Laboratory Standards recommended by the Laboratory for Diagnosis of Dysentery and Cholera in collaboration with the Centers for Disease Control and Prevention and the WHO Africa Region were used. Results The drug resistance rates of the two strains of dysentery strains showed no significant difference (P> 0.05) except the nalidixic acid (P <0.05). Conclusion Different types of dysentery strains of the same community in addition to the genus of Neisseria gonorrhoeae, have more than two kinds of drug resistance patterns. Drug-resistant patterns can make up for the lack of an epidemiological link between single-serotype probing cases.