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目的 :探讨新生儿缺氧缺血性脑病 (HIE)甲状腺激素的变化及临床意义。方法 :采用放射免疫分析法对6 0例HIE病人进行血清甲状腺激素测定 ,同时设对照组。结果 :本组病例血清T3 、FT3 值明显低于对照组 ;中～重度组低于轻度组 ,两组比较有显著差异。中～重度组不仅血清T3 、FT3 水平明显降低 ,而且T4 也可降低。本组病例低T3 综合症、低甲状腺血症、高T4 综合症 (中～重度组无 1例 )发生率分别为 6 8 6 3%、11 6 7%、3 33%。结论 :本病血清甲状腺激素的变化与病情的轻重程度密切相关 ,可作为判断疾病的严重程度及预后的实验室指标。
Objective: To investigate the changes and clinical significance of thyroid hormones in neonates with hypoxic-ischemic encephalopathy (HIE). Methods: Serum thyroid hormone was measured in 60 HIE patients by radioimmunoassay, and the control group was also established. Results: Serum T3 and FT3 levels in this group were significantly lower than those in the control group, moderate to severe group was lower than in the mild group, there was significant difference between the two groups. In the moderate to severe group, not only serum T3, FT3 levels were significantly lower, but also T4 can be reduced. The incidence of low T3 syndrome, hypothyroidism, and high T4 syndrome (none of the moderate-severe cases) in this group of patients were respectively 6 8 6 3%, 11 6 7%, 3 33%. Conclusion: The change of serum thyroid hormones is closely related to the severity of the disease, which can be used as a laboratory index to judge the severity and prognosis of the disease.