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1994年Zhang等人通过定向克隆技术首次发现了ob基因和该基因编码的蛋白产物—瘦素,瘦素的发现给肥胖及能量代谢领域带来了一次重大突破。瘦素不仅仅只对能量代谢起作用,它在病理生理学上的影响涉及许多系统。
In 1994, Zhang et al. First discovered the ob gene and the protein product encoded by this gene - leptin through directional cloning technology. The discovery of leptin brought a major breakthrough in the field of obesity and energy metabolism. Leptin not only acts on energy metabolism, its pathophysiological impact involves many systems.