论文部分内容阅读
目的 :观察胆道梗阻后心肌损伤及黄芪 (AM)的保护作用。 方法 :动态观测心肌组织丙二醛 (MDA)和超氧化物歧化酶 (SOD)、血清T Bil、TBA、内毒素 (ET)、肿瘤坏死因子 (TNFα)含量 ;取左室心肌行光电镜检查 ,应用ABC免疫组化染色法 ,定位TNFα 在心肌组织中的表达和分布。 结果 :胆道梗阻后 ,血清T Bil、TBA、ET、TNFα 水平逐渐升高 ,心肌组织MDA含量逐渐升高 ,SOD逐渐减少 ;各AM治疗组与同时相梗阻组比较 ,血清ET、TNFα、心肌组织MDA含量减少 ,SOD含量升高 ;心肌组织MDA含量与血清TNFα 含量变化呈正相关 ;光电镜下可见随胆道梗阻时间延长 ,心肌组织细胞损害加重 ,各AM治疗组与同时相梗阻组比较组织细胞损害减轻。 结论 :AM通过对抗自由基损伤、内毒素血症、TNFα 的综合作用 ,对胆道梗阻所致心肌损伤有明显保护作用
Objective: To observe the myocardial damage and the protective effect of jaundice (AM) after biliary obstruction. Methods: The contents of malondialdehyde (MDA) and superoxide dismutase (SOD), serum T Bil, TBA, endotoxin (ET) and tumor necrosis factor (TNFα) in myocardial tissue were observed dynamically; The application of ABC immunohistochemical staining to locate the expression and distribution of TNFα in myocardial tissue. Results: After bile duct obstruction, the levels of serum T Bil, TBA, ET, and TNF α increased gradually, and the content of MDA in myocardial tissue gradually increased, and the SOD gradually decreased. The levels of serum ET, TNF α, and myocardial tissue were compared in each AM treatment group and concurrent obstruction group. The content of MDA decreased and the content of SOD increased. There was a positive correlation between the content of MDA in the myocardial tissue and the level of serum TNFα. Under the photoelectric microscope, the damage of the myocardium was worsened with the prolonged duration of biliary obstruction. The histopathological damage was compared between the AM treatment group and the simultaneous obstruction group. Reduce. Conclusion :AM has a protective effect against myocardial damage caused by biliary obstruction through the combined action of free radical damage, endotoxemia and TNFα.