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目的:探讨依托咪酯联合芬太尼在无痛人工流产中的应用效果。方法:选取2007年4月～2009年4月,来我院自愿要求人工流产而无禁忌症及并发症者800例,随机分为实验组和对照组,每组400例,实验组患者应用依托咪酯加芬太尼,对照组患者应用笑气联合利多卡因宫旁注射,分析2组患者手术过程中的镇痛效果、副反应、出血量、血压的变化情况。结果:2组孕者经不同麻醉药物麻醉后镇痛效果比较,实验组总有效率96.5%明显高于对照组总有效率93.25%(P<0.05)。麻醉前后出血量无明显差异(P>0.05),实验组术前术后收缩压及舒张压变化幅度小于对照组;恶心呕吐发生情况比较无明显差异;实验组肌颤发生机率低于对照组(P<0.05),实验组呼吸抑制发生率高于对照组(P<0.05)。结论:依托咪酯联合芬太尼用于无痛人工流产,手术的镇静/镇痛效果满意,从而达到无痛流产的目的。
Objective: To investigate the efficacy of etomidate combined with fentanyl in painless induced abortion. Methods: From April 2007 to April 2009, 800 patients who voluntarily requested abortion without contraindications and complications in our hospital were randomly divided into experimental group and control group with 400 cases in each group. The patients in experimental group were relied on Mifepristone and mifepristone. Patients in the control group were treated with nocturnal injection of lidocaine and uterine artesunate. The analgesic effects, side effects, blood loss and blood pressure were analyzed during the operation of the two groups. Results: Compared with the control group, the total effective rate of 96.5% in the experimental group was significantly higher than that of the control group (93.25%, P <0.05). There was no significant difference in bleeding volume before and after anesthesia (P> 0.05). The change of systolic blood pressure and diastolic blood pressure before and after operation in experimental group were less than those in control group. There was no significant difference in the occurrence of nausea and vomiting. The incidence of fibrillation in experimental group was lower than that in control group P <0.05). The incidence of respiratory depression in the experimental group was higher than that in the control group (P <0.05). Conclusion: Etomidate combined with fentanyl for painless abortion, the effect of sedation / analgesia is satisfactory, so as to achieve the purpose of painless abortion.