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早在1948年Conley等就发现血小板具有中和肝素的活性。该活性被命名为血小板Ⅳ因子(Platelct Factor 4,PF4)。以后发现,血小板口颗粒中存在多种抗原性不同的抗肝素蛋白,其中作用最大者称之为高亲和性PF4(High
As early as 1948, Conley et al. Found that platelets have the activity of neutralizing heparin. This activity was named Platelct Factor 4 (PF4). Later found that there are a variety of antigens in the platelet population of anti-heparin protein, of which the role of the most high-affinity PF4 (High