用于多肽新药研发的化学修饰的专利技术该项目针对制约多肽药物发展的瓶颈问题,致力于研究多肽药物的化学修饰的核心技术。首次提出了肽类药物分子“阴阳平衡”新策略,并突破了内吗啡肽难以通透血脑屏障的瓶颈问题;通过合理引入特殊的化学结构,解决了若干多肽的分子稳定性差的问题;基于系统的构效关系和作用机制研究, Patented Technology for Chemical Modification of Peptide New Drugs This project aims to study the core technology of chemical modification of peptide drugs in view of the bottleneck that restricts the development of peptide drugs. For the first time, a new strategy of “Yin-Yang balance” for peptide drugs was proposed and the bottleneck problem of endoporphyrin difficult to penetrate the blood-brain barrier was solved. The problem of poor molecular stability of several peptides was solved by reasonably introducing a special chemical structure Based on the study of structure-activity relationship and mechanism of system,