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丝裂霉素C(MMc)诱导的姐妹染色单体互换(SCE)可反映出细胞DMA损伤修复的基本过程。有关MMC诱发活体的SCE研究不多。本实验目的,就是探讨MMC诱发小白鼠骨髓细胞SCE的剂量—效应关系,并对SCE指标与染色体畸变指标,在检测机体DNA损伤上的差异作一比较研究。结果证明,MMC诱发染色体畸变能办远低于诱发SCE的能力,MMC可诱发小白鼠骨髓细胞SCE产生,SCE值随MMC剂量的增加而增加。SCE即使在低剂量诱变剂的作用下也是敏感的。
The mitochondrial C (MMc)-induced sister chromatid exchange (SCE) may reflect the basic process of cellular DMA injury repair. There are few SCE studies on MMC-induced living organisms. The purpose of this experiment is to investigate the dose-effect relationship of MMC-induced SCE in bone marrow cells of mice, and to compare the differences in SCE markers and chromosomal aberration indicators in the detection of DNA damage in mice. The results showed that MMC induced chromosomal aberrations can be far lower than the ability to induce SCE, MMC can induce bone marrow cell SCE production in mice, SCE value increases with the increase in the dose of MMC. SCE is sensitive even under the influence of low-dose mutagens.