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据文献报告镁有降低周身血管阻力,扩张冠状动脉,降低血小极聚集,改善心肌代谢,保护心肌以避免儿茶酚胺所致之心肌坏死及稳定细胞膜的作用。镁盐价格低廉,应用方便。按理镁盐在AMI治疗常规中应占有一重要地位,但实际情况并非如此。曾有几组小规模关于镁盐治疗的临床试验,结果或认为镁盐疗效无统计学意义,或研究者本人因鉴于试验规模小而在作出结论方面特审慎态度,因此对这一问题作一次级分析是有价值的。作者检索MEDLINE光盘,搜集到420篇论及镁和心肌硬塞的报告,但其中论述死亡者仅14篇。14篇中又仅8篇附合作者选用的随机的、设置对照
According to the literature, magnesium can reduce global vascular resistance, dilate coronary arteries, reduce polar aggregation, improve myocardial metabolism, protect myocardium from catecholamine-induced myocardial necrosis and stabilize cell membranes. Magnesium salt cheap, easy to use. Logical magnesium salts in AMI treatment routine should occupy an important position, but the fact is not the case. There have been several small-scale clinical trials on the treatment of magnesium salts, with the result that there was no statistically significant effect on the efficacy of magnesium salts or that the investigators themselves were particularly cautious in concluding their conclusions because of the small size of the trials Level analysis is valuable. The authors searched the MEDLINE CD-ROM and collected 420 reports on magnesium and myocardial infarction, but only 14 of them were discussed. Of the 14 articles, only 8 were randomized, setting controls