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目的探析内镜超声引导下细针穿刺活检物(EUS-FNA)中CEA、CA19-9肿瘤标志物的测定在胰腺癌临床诊断中的应用价值。方法选择宝安区松岗人民医院及中山大学附属肿瘤医院2011年7月~2013年8月期间收治的52例胰腺癌患者作为观察组,另以52例慢性胰腺炎患者作为对照组,对两组患者血清以及EUS-FNA中CEA、CA19-9肿瘤标志物水平进行测定,比较两种方法的敏感性。结果观察组EUS-FNA物中测定的CEA以及CA19-9水平分别为(208.2±36.5)μg/L、(655.9±104.4)U/m L,显著高于血清测定水平,对比差异明显(P<0.05)。对照组EUS-FNA物中测定CEA以及CA19-9水平分别为(4.1±1.0)μg/L、(19.9±6.7)U/m L,与血清测定结果比较无显著差异(P>0.05)。EUS-FNA检测方法所测定得到的CEA敏感度与特异度、CA19-9敏感度、联合检测敏感度与特异度均高于对照组,比较有统计学意义(P<0.05)。结论 EUS-FNA测定肿瘤标志物CEA、CA19-9在胰腺癌患者中的临床诊断中具有较高价值,联合检测可进一步提高敏感性。
Objective To investigate the value of CEA and CA19-9 tumor markers in the diagnosis of pancreatic cancer by endoscopic ultrasonography guided fine needle aspiration (EUS-FNA). Methods A total of 52 patients with pancreatic cancer who were admitted to Songgang People’s Hospital of Bao’an District and affiliated oncology hospital of Sun Yat-sen University from July 2011 to August 2013 were selected as observation group and 52 patients with chronic pancreatitis as control group. Patient serum, and CEA, CA19-9 tumor marker levels in EUS-FNA were measured to compare the sensitivity of the two methods. Results The levels of CEA and CA19-9 in the EUS-FNA of the observation group were (208.2 ± 36.5) μg / L and (655.9 ± 104.4) U / m L, respectively, which were significantly higher than those of the serum and the difference was significant (P < 0.05). The levels of CEA and CA19-9 in the control group were (4.1 ± 1.0) μg / L and (19.9 ± 6.7) U / mL, respectively. There was no significant difference between the two groups (P> 0.05). The CEA sensitivity and specificity, CA19-9 sensitivity and the combined detection sensitivity and specificity of EUS-FNA were higher than those of the control group (P <0.05). Conclusion The detection of tumor markers CEA and CA19-9 by EUS-FNA has high value in the clinical diagnosis of patients with pancreatic cancer, and the combined detection can further improve the sensitivity.