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目的研究胰腺癌组织中iNOS的表达与淋巴结转移的关系。方法采用免疫组织化学染色(SP法),光镜下进行iNOS阳性细胞评分,用SPSS10.0统计软件进行统计分析。结果胰腺癌组织中iNOS的表达阳性率为54%(19/35),评分(3.17±1.22)明显高于正常组织(0.5±0.54,P<0.01)。淋巴结转移组iNOS的表达(3.89±2.31)较未转移组明显增高(2.14±1.74,P<0.05)。iNOS的表达与其他胰腺癌临床和病理分期均有明显关系(P<0.05)。结论iNOS的表达与胰腺癌的淋巴结转移有密切关系,与胰腺癌的临床和病理分期也有明显关系。
Objective To study the relationship between iNOS expression and lymph node metastasis in pancreatic cancer. Methods Immunohistochemical staining (SP method) was used to score iNOS positive cells under light microscope. Statistical analysis was performed with SPSS10.0 statistical software. Results The positive rate of iNOS expression in pancreatic cancer was 54% (19/35), which was significantly higher than that in normal tissues (3.17 ± 1.22, P <0.01). The expression of iNOS in lymph node metastasis group (3.89 ± 2.31) was significantly higher than that in non-metastasis group (2.14 ± 1.74, P <0.05). The expression of iNOS was significantly correlated with the clinical and pathological stages of other pancreatic cancers (P <0.05). Conclusions The expression of iNOS is closely related to the lymph node metastasis of pancreatic cancer and has a significant relationship with the clinical and pathological stage of pancreatic cancer.