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近年来,色甘酸钠已被广泛用于治疗成人及6岁以上儿童的变应性鼻炎,其作用机制,尚不十分清楚。动物模型研究提示其主要作用是在变应原与IgE抗体结合后抑制肥大细胞对炎性介质和非免疫介质的释放。据文献报道,色甘酸钠对季节性及常年性鼻炎均有良效。经临床实践证明,本药溶液鼻内喷雾优于粉剂,浓度以4％最佳。每次喷雾剂量为5.2mg,其中约有7％在鼻腔吸收,经胆道及小便排泄,剩下的咽下或呼出,经胃肠吸收的不到2％。每日用药次数按病情决定,在发病季节或急性
In recent years, cromolyn sodium has been widely used to treat allergic rhinitis in adults and children over 6 years of age, and its mechanism of action is not yet clear. Animal models suggest that its main role is to inhibit the release of inflammatory and non-immune mediators from mast cells after allergen and IgE antibodies bind. According to the literature, cromolyn sodium has a good effect on both seasonal and perennial rhinitis. Proved by clinical practice, the nasal spray solution is better than powder, the best concentration of 4%. Each spray dose of 5.2mg, of which about 7% absorption in the nasal cavity, biliary and urinary excretion, the remaining swallowed or exhaled, less than 2% of gastrointestinal absorption. Daily medication according to the number of decisions, in the onset of the season or acute