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目的了解杭州市余杭区麻疹疫苗的初免成功率情况,为控制麻疹高发提供参考。方法2008年6-8月在临平地区、塘栖地区、瓶窑地区各抽取1个预防接种门诊,共对77名刚满8月龄的儿童,按自愿原则,在麻疹疫苗免疫前采集1份血清、免疫后30 d采集第2份血清进行抗体滴度检测,其中57名儿童符合麻疹减毒活疫苗初免成功率调查要求。结果57名儿童免疫前有4名儿童为抗体阳性,阳性率为7.02%;免疫后1个月麻疹抗体阳转率达100%。临平街道与瓶窑镇、塘栖镇与瓶窑镇免疫接种后平均抗体滴度差异有统计学意义,提示临平街道、塘栖镇均高于瓶窑镇。结论杭州市余杭区麻疹疫苗接种有效,抗体阳转率高,免疫前麻疹抗体阳性的儿童,接种麻疹疫苗,提示可以增加抗体滴度,可以有利于保护杭州市余杭区儿童身体健康;同时也提示杭州市余杭区不同地区麻疹疫苗的接种质量可能存在差异,应加强接种人员的培训,提高接种质量。
Objective To understand the initial immunization success rate of measles vaccine in Yuhang District of Hangzhou City and provide reference for controlling the high incidence of measles. Methods From June to August in 2008, a total of 1 outpatient vaccination clinic was taken in Linping, Tangxi, and Jingyao areas. A total of 77 children aged 8 months were enrolled in a random sample of 1 Serums were collected 30 days after immunization, the second serum was collected for antibody titer test, of which 57 children met the initial success rate of live attenuated measles vaccine investigation requirements. Results Four of the 57 children before immunization were positive for the antibody, the positive rate was 7.02%. One month after the immunization, the positive rate of measles antibody was 100%. The average antibody titers of Linping street and bottle kiln town, Tangqi town and bottle kiln town were significantly different after vaccination, which indicated that Linping street and Tangqi town were higher than that of bottle kiln town. Conclusion Measles vaccination is effective in Yuhang District of Hangzhou City, with high antibody positive rate. Immunization of measles-positive children with immunization against measles vaccine suggests that it can increase the antibody titer and protect the health of children in Yuhang District of Hangzhou City. There may be differences in the quality of measles vaccination in different areas of Yuhang District, Hangzhou. Vaccination staff should be trained to improve vaccination quality.