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为保证中、晚期肝癌的非手术疗法—肝动脉灌注~(131)I—碘化油的安全性,用~(131)I—标记碘化油给予实验犬4只进行动脉灌注,以观察体内分布、代谢.肝脏分布为74.38%～91.36%,经微循环达双肺仅为2.45%～8.57%.~(131)I—碘化油在肝、肺的有效半衰期分别为4、35±0.62天和5.23±0.88天.主要由肾脏排出,每天排泄量相对恒定,为注入剂量的2.6%～5.7%.由类便排泄的活性甚微,每日排泄仅为注入量的0.01%左右.结果表明~(131)I—碘化油行肝动脉灌注治疗中、晚期肝癌不会造成肝外器官损伤.
To ensure the safety of hepatic arterial infusion of ~(131)I-iodinated oil for the non-surgical therapy of middle and late stage liver cancer, four experimental dogs were given 131I-labeled iodized oil for arterial perfusion to observe the body. Distribution, metabolism, liver distribution of 74.38% to 91.36%, after the microcirculation of lungs only 2.45% ~ 8.57%. ~ (131) I - iodized oil in the liver, lung effective half-life of 4,35 ± 0.62, respectively Days and 5.23±0.88 days. Mainly excreted by the kidneys, the daily excretion is relatively constant, 2.6% to 5.7% of the injected dose. The activity excreted by the feces is minimal, and the daily excretion is only about 0.01% of the injected amount. It was indicated that ~(131)I-iodinated oil in hepatic arterial infusion can not cause extrahepatic organ damage in middle and late stage liver cancer.