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Zeolitic imidazolate framework-8 (ZIF-8),composed of Zn ions and imidazolate ligands,is a class of metal-organic frameworks,which possesses a similar structure as conventional aluminosilicate zeolites.This material exhibits inherent porous property,high loading capacity,and pH-sensitive degradation,as well as exceptional thermal and chemical stability.Extensive research effort has been devoted to relevant research aspects ranging from synthesis methods,property characterization to potential applications of ZIF-8.This review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug delivery.The potential risks of using ZIF-8 for drug delivery are also summarized.