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目的 探讨局部应用ＩＬ－２ 联合化疗治疗口腔鳞癌的临床疗效。方法 对２４例口腔鳞癌患者，分别行单纯化疗、化疗联合瘤体局部应用ＩＬ－２，比较给药前后肿瘤的大小变化及病理表现。结果 局部应用ＩＬ－２ 联合化疗治疗口腔鳞癌１４ 例，其中ＣＲ２ 例，ＰＲ８ 例，ＭＲ４ 例，有效率为７１．４％ ，而单纯化疗的１０ 例患者，ＰＲ５ 例，ＭＲ３例，ＮＲ２ 例，有效率为５０％ 。病理切片显示：ＩＬ－２ 联合化疗组大片癌细胞崩解、坏死，间质及癌巢中大量淋巴细胞浸润、纤维组织增生；单纯化疗组仅见大片癌细胞崩解、坏死，而淋巴细胞浸润少见。结论 局部应用ＩＬ－２ 联合化疗治疗口腔鳞癌可取得较好临床疗效，肿瘤局部免疫力增强。其远期效果有待进一步观察。
Objective To investigate the clinical efficacy of topical application of IL-2 combined with chemotherapy in the treatment of oral squamous cell carcinoma. Methods Twenty-four patients with oral squamous cell carcinoma were treated with chemotherapy and chemotherapy combined with local application of IL-2. The size and pathological changes of tumor before and after administration were compared. Results The application of IL-2 in combination with chemotherapy in the treatment of oral squamous cell carcinoma in 14 cases, of which CR2, PR8 and MR4 cases, the effective rate was 71.4%, while chemotherapy alone in 10 patients, PR5 cases, MR3 cases, NR2 cases, Effective rate of 50%. Pathological sections showed that a large number of cancer cells in IL-2 combined chemotherapy group were disintegrated and necrotic, with a large number of lymphocytic infiltration and fibrous tissue hyperplasia in the stroma and cancer nests. In the simple chemotherapy group, only a large number of cancerous cells disintegrated and necrotic, while infiltration of lymphocytes was rare . Conclusion Local application of IL-2 combined with chemotherapy for oral squamous cell carcinoma can achieve better clinical curative effect, and local tumor immunity is enhanced. Its long-term effect needs further observation.