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目的探讨牙齿缺失与胃癌患者生存的关系,为胃癌的防治提供参考依据。方法采用多因素Cox回归分析方法,对河南省林县营养干预试验随访24年中发生原发性胃癌患者2 084例进行牙齿缺失与胃癌患者生存关系的分析。结果随访5年结果表明,调整年龄、吸烟、饮酒、体质指数、肿瘤家族史、饮食情况、临床分期和治疗方法后,男、女性牙齿缺失与胃癌患者死亡风险均无关(P>0.05);随访15年和24年结果表明,牙齿缺失与胃癌患者死亡风险均无关(P>0.05);对不同程度牙齿缺失情况进一步分级分析表明,牙齿缺失与胃癌患者死亡风险无关(P>0.05),牙齿缺失Ⅰ、Ⅱ、Ⅲ级胃癌患者5年生存率分别为26.79%、18.28%、17.61%,不同级别牙齿缺失胃癌患者生存率间差异有统计学意义(χ2=21.521,P<0.001)。结论男性牙齿缺失与胃癌生存无关,女性牙齿缺失同样与胃癌患者死亡风险无关。
Objective To investigate the relationship between tooth loss and survival of gastric cancer patients, and provide reference for prevention and treatment of gastric cancer. Methods A multivariate Cox regression analysis was used to analyze the relationship between tooth loss and survival in 2 gastric cancer patients with primary gastric cancer in 24 years’ follow-up of nutritional intervention trials in Lin County, Henan Province. Results The results of follow-up 5 years showed that after adjustment of age, smoking, alcohol consumption, body mass index, family history of cancer, diet, clinical stage and treatment methods, there was no relationship between tooth loss in males and females and death risk of gastric cancer (P>0.05); The 15-year and 24-year results showed that tooth loss was not associated with the risk of death in patients with gastric cancer (P>0.05); further graded analysis of tooth loss in different degrees showed that tooth loss was not associated with death risk in patients with gastric cancer (P>0.05). The 5-year survival rates of patients with type I, II, and III gastric cancer were 26.79%, 18.28%, and 17.61%, respectively, and there was a statistically significant difference in the survival rate among patients with different grades of missing teeth (χ2=21.521, P<0.001). Conclusion The loss of male teeth is not related to the survival of gastric cancer. The loss of female teeth is also not associated with the death risk of gastric cancer patients.