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目的探讨急诊创伤患者血清中C-反应蛋白/脂联素水平与患者胃肠功能、病情及预后的关系。方法选取2015年8月-2016年4月在本院诊断为急诊创伤的患者90例,检测患者血液中C-反应蛋白(CRP)和脂联素(APN)水平,采用胃肠功能评分评价患者胃肠功能、采用APACHEⅡ评分评价患者病情、分析CRP/脂联素与患者胃肠功能和病情的关系及预后的关系。结果本研究中共16例患者为预后不良,预后不良组患者血清CRP、CRP/APN水平高于预后良好组,而APN水平低于预后良好组,差异有统计学意义(P<0.05)。CRP、CRP/APN水平与胃肠功能、血清DAO、D-乳糖、APACHEⅡ评分呈正相关,而APN与胃肠功能、血清DAO、D-乳糖、APACHEⅡ评分呈负相关(P<0.05)。APN、CRP/APN、APACHEⅡ评分是患者死亡的独立风险因素(P<0.05)。结论急诊创伤患者血清中CRP/ANP与患者预后密切相关。
Objective To investigate the relationship between serum C-reactive protein and adiponectin level, gastrointestinal function, disease status and prognosis in emergency trauma patients. Methods Ninety patients diagnosed as emergency trauma in our hospital from August 2015 to April 2016 were enrolled in this study. The levels of C-reactive protein (CRP) and adiponectin (APN) in the blood of the patients were measured. The gastrointestinal function score was used to evaluate the patients Gastrointestinal function, using APACHE Ⅱ score evaluation of the patient’s condition, analysis of CRP / adiponectin and gastrointestinal function and the relationship between patients and prognosis. Results A total of 16 patients in our study had poor prognosis. The patients with poor prognosis had higher serum CRP and CRP / APN levels than those with good prognosis, while the APN levels were lower than those with good prognosis (P <0.05). CRP and CRP / APN levels were positively correlated with gastrointestinal function, serum DAO, D-lactose and APACHEⅡscore, while APN was negatively correlated with gastrointestinal function, serum DAO, D-lactose and APACHEⅡscore (P <0.05). The APN, CRP / APN and APACHE Ⅱ scores were independent risk factors for death (P <0.05). Conclusion The serum CRP / ANP levels in emergency trauma patients are closely related to the prognosis of patients.