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内皮细胞能产生分泌纤溶酶原激活物 (t- PA )和 t- PA抑制剂 (PAI- 1) ,调节凝血和纤溶的平衡。 t- PA通过激活纤溶酶原 ,启动纤维蛋白的降解过程。 PAI- 1是 t- PA的生理性抑制剂 ,是纤溶系统功能的重要调节因子。体内外实验均表明 ,PAI- 1活性及含量可因炎症及动脉粥样硬化相
Endothelial cells produce secreted plasminogen activator (t-PA) and t-PA inhibitor (PAI-1), regulating the balance of coagulation and fibrinolysis. t-PA initiates fibrin degradation by activating plasminogen. PAI-1 is a physiologic inhibitor of t-PA and is an important regulator of fibrinolytic system function. In vitro and in vivo experiments have shown that PAI-1 activity and content may be due to inflammation and atherosclerosis phase