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作者观察了硝酸甘油加小剂量垂体后叶素持续静脉滴注抢救肝硬化门脉高压上消化道出血的临床疗效。治疗组以硝酸甘油10mg及垂体后叶素100u加于5%葡萄糖液500ml中,以每分钟1ml的滴速持续静脉滴注24小时,如呕血控制,将以上两药的半量继续静脉滴注48～72小时,而后停药;对照组以垂体后叶素40u加于5%葡萄糖液500ml中,每天静滴,必要时重复一次。治疗结果表明,治疗组出血的满意控制率为90%,对照组出血的满意控制率为40%,两者相比有差异(P<0.005)。治疗组用药后未发现有心梗或心绞痛等副作用,说明硝酸甘油与垂体后叶素合用可以提高疗效并减少垂体后叶素的副作用。
The authors observed the clinical efficacy of nitroglycerin plus a small dose of vasopressin sustained intravenous rescue of cirrhotic patients with portal hypertension on upper gastrointestinal bleeding. The treatment group with nitroglycerin 10mg and vasopressin 100u added to 500ml of 5% glucose solution to drip rate of 1ml per minute continuous intravenous infusion of 24 hours, such as hematemesis control, the above two half of the amount of intravenous infusion of 48 ~ 72 hours, and then discontinued; control group pituitrin 40u added to 500ml of 5% glucose solution, intravenous infusion, if necessary, repeated. The results showed that the satisfactory rate of hemorrhage was 90% in control group and 40% in control group, the difference was significant (P <0.005). The treatment group found no side effects such as myocardial infarction or angina after treatment, indicating that nitroglycerin combined with pituitrin can improve the curative effect and reduce the side effects of vasopressin.