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目的 探讨尿微量白蛋白 (ALB)和血、尿α1 微球蛋白 (α1 MG)测定在早期发现糖尿病肾病、高血压肾病中的应用价值。方法 ALB和α1 MG检测采用放射免疫分析法 (RIA) ,血、尿肌酐测定采用碱性苦味酸法。结果血、尿α1 MG、尿ALB阳性率明显高于血Cr阳性率 ,差异有显著性 (P <0 0 0 5 )。尿ALB 尿α1 MG ,血α1 MG 尿α1 MG之比值在两病患者间亦有显著差异 ,高血压肾病高于糖尿病肾病 (P <0 .0 0 1和P <0 0 5 )。结论 α1 MG、ALB的检测对于糖尿病肾病、高血压肾病的早期诊断以及肾功能损伤程度、部位的判定具有一定的价值。
Objective To investigate the value of urine microalbumin (ALB) and blood α1 microglobulin (α1 MG) in the early detection of diabetic nephropathy and hypertensive nephropathy. Methods ALB and α1 MG were detected by radioimmunoassay (RIA), blood and urine creatinine were measured by alkaline picric acid method. Results The positive rate of blood and urine α1 MG and urine ALB was significantly higher than that of blood Cr, the difference was significant (P <0.05). Urinary ALB urinary α1 MG, blood α1 MG urinary α1 MG ratio was also significantly different between the two patients, hypertensive nephropathy was higher than diabetic nephropathy (P <0 01 and P 0 05). Conclusion The detection of α1 MG and ALB has certain value for the early diagnosis of diabetic nephropathy and hypertensive nephropathy as well as the degree and location of renal injury.