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目的探讨基质金属蛋白酶－９（ＭＭＰ－９）表达与胃癌侵袭转移及预后的关系。方法采用ＳＰ免疫组织化学方法，检测２０例正常胃黏膜上皮。２０例异型增生、１０８例胃癌组织及４７例相应癌转移淋巴结ＭＭＰ－９的表达情况。结果正常胃黏膜和异型增生ＭＭＰ－９阳性表达率分别为２０．０％（４／２０）和７０％（１４／２０），均呈弱阳性表达；胃癌组织ＭＭＰ－９表达阳性率为８８．９％（９６／１０８），显著高于前两者（Ｐ＜０．０５）；癌转移淋巴结ＭＭＰ－９阳性表达率为１００％（４７／４７），明显高于胃癌原发灶（Ｐ＜０．０５）；ＭＭＰ－９表达强度与胃癌细胞分化程度无明显相关（Ｐ＞０．０５），与胃癌生长方式、浸润深度、淋巴结转移、远处转移、脉管侵犯及病期密切相关（均Ｐ＜０．０５；ＭＭＰ－９强阳性表达胃癌患者术后５年生存率明显下降（Ｐ＜０．０５）。结论ＭＭＰ－ ９表达与胃癌侵袭转移及预后密切相关。
Objective To investigate the relationship between matrix metalloproteinase-9 (MMP-9) expression and invasion, metastasis and prognosis of gastric cancer. Methods SP immunohistochemical method was used to detect 20 cases of normal gastric mucosal epithelium. The expression of MMP-9 was detected in 20 cases of dysplasia, 108 cases of gastric cancer, and 47 cases of corresponding metastatic lymph nodes. Results The positive expression rates of MMP-9 in normal gastric mucosa and dysplasia were 20.0% (4/20) and 70% (14/20), respectively. They all showed weak positive expression. The positive rate of MMP-9 expression in gastric cancer tissues was 88. 9% (96/108) was significantly higher than the former two (P<0.05); the positive expression rate of MMP-9 in metastatic lymph nodes was 100% (47/47), which was significantly higher than that of primary gastric cancer (P< 0.05); The intensity of MMP-9 expression was not significantly related to the differentiation of gastric cancer cells (P>0.05). It was closely related to the growth pattern of gastric cancer, depth of invasion, lymph node metastasis, distant metastasis, vascular invasion and disease stage ( All P<0.05;5-year survival rate of gastric cancer patients with strongly positive expression of MMP-9 decreased significantly (P<0.05).Conclusion The expression of MMP-9 is closely related to the invasion, metastasis and prognosis of gastric cancer.