【摘 要】
：
乙烯菌核利在哺乳动物实验中被广泛证实具有抗雄激素效应,而对鱼类的研究结论目前并不统一.将性成熟稀有(鱼)鲫分别暴露于0、2、10、50μg·L-1乙烯菌核利21 d,研究环境浓度
【机 构】
：
中国科学院生态环境研究中心环境水质学国家重点实验室
【基金项目】
：
国家高技术研究发展计划“863计划”重大项目;
论文部分内容阅读
乙烯菌核利在哺乳动物实验中被广泛证实具有抗雄激素效应,而对鱼类的研究结论目前并不统一.将性成熟稀有(鱼)鲫分别暴露于0、2、10、50μg·L-1乙烯菌核利21 d,研究环境浓度下乙烯菌核利对鱼类生殖系统的影响及作用机制.结果表明,雌鱼的性腺指数(GSI)、肝脏指数(HSI)在所有浓度组均显著降低(p＜0.05),同时卵巢组织中卵泡的发育受到了抑制;而雄鱼仅HSI在最高浓度组(50 μg·L-1)出现显著降低(p＜0.05),精巢组织切片也未观察到明显损伤,说明乙烯菌核利对雌鱼生殖系统的影响大于雄鱼.在转录水平上,雌鱼性腺中er mRNA、vtg mRNA分别在50μg·L-1和10、50μg·L-1时显著升高(p＜ 0.05),armRNA在所有浓度组显著升高(p＜0.05);而雄鱼性腺中ar mRNA、dmrtl mRNA水平分别在10 μg· L-1浓度组和所有浓度组显著降低(P＜0.05),er mRNA在所有浓度组显著降低(p＜0.05),说明雌雄鱼对乙烯菌核利暴露的分子响应机制存在差异.综上,环境浓度下乙烯菌核利短期暴露会对稀有(鱼)鲫生殖系统产生一定的影响,并且雌雄鱼在敏感性和分子响应机制上都存在差异.
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