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应用ICS-Ⅱ型免疫化学自动分析仪测定67例胃癌和201例良性胃疾病胃液中α_1酸性糖rrrrrrrrn蛋白和前白蛋白水平,探讨其对胃癌临床诊断的价值以及与胃癌临床病理分期、浸润深度和转移的关rrrrrrrrn系。结果表明,胃癌胃液α_1酸性糖蛋白水平显著高于良性胃疾病(P<0.05);胃液前白蛋白水平相互rrrrrrrrn间无明显差别(P>0.05)。α_1酸性糖蛋白诊断界限为10mg·L-1,诊断敏感性79.10%,特异性80.60%,rrrrrrrrn准确性80.22%。随胃癌临床病理分期和淋巴结转移的进展,以及浸润深度的加深,α_1酸性糖蛋白水平rrrrrrrrn亦趋增高。而浸润深度为T4时反而回落,但统计学分析各期差异无显著意义。提示测定胃液α_1酸性糖rrrrrrrrn蛋白对诊断胃癌有一定的临床价值,其水平变化与胃癌临床病理分期、浸润深度和淋巴结转移的关系有rrrrrrrrn待于进一步研究。
An ICS-II immunochemistry automatic analyzer was used to measure the levels of α_1 acid sugar and protein and prealbumin in gastric juice in 67 patients with gastric cancer and 201 patients with benign gastric disease. To explore the value of clinical diagnosis of gastric cancer and the relationship between clinical pathological staging, depth of invasion, and metastasis of gastric cancer. The results showed that the level of α_1 acid glycoprotein in gastric juice was significantly higher than that in benign gastric disease (P<0.05); the levels of pre-gastric albumin were not correlated with each otherrrrrrrrn Significant difference (P>0.05). The diagnostic limit of α_1 acid glycoprotein was 10 mg·L-1, the sensitivity was 79.10%, the specificity was 80.60%, and the accuracy was 80.0%. twenty two%. With the progression of clinical pathological stage and lymph node metastasis of gastric cancer, and the deepening of infiltration depth, α_1 acid glycoprotein levels also tend to increase. However, the infiltration depth decreased to T4, but there was no significant difference in statistical analysis. Prompt measurement of gastric juice α_1 acidic sugarrrrrrrrrnprotein has certain clinical value in the diagnosis of gastric cancer, and its level changes are related to the clinical pathological stage, depth of invasion and lymph node metastasis of gastric cancer. There are rrrrrrrrn pending further study.