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作者报道5例缺乏B细胞而T细胞功能正常的丙种球蛋白缺乏症患者发生中枢神经系统的ECHO病毒感染持久达3年者。病期中脑脊液均多次分离出ECHO30,19,9,33等型病毒,临床表现较少急性中枢神经系感染的症状,3例颇似皮肌炎(肌肉未分离出病毒),死亡1例的尸检除神经系有单核细胞浸润外,无任何病毒感染的征象,说明抗体在炎症反应的
The authors report that in 5 patients with gamma globulin deficiency who lack B cells and whose T cells function normally, central nervous system ECHO virus infection persists for 3 years. ECHO30, 19, 9, 33 and other viruses were isolated from cerebrospinal fluid in multiple stages during the disease, with less clinical manifestations of acute central nervous system infection, 3 cases of dermatomyositis (muscle without isolating the virus) and 1 case of death Autopsy in addition to mononuclear cell infiltration of the nervous system, without any signs of viral infection, indicating that the antibody in the inflammatory response