Success of plants largely depends on their ability to defend against herbivores.Since emergence of the first voracious consumers,plants maintained adapting their structures and chemistry to escape from extinction.The constant pressure was further accelerated by adaptation of herbivores to plant defenses,which all together sparked the rise of a chemical empire comprised of thousands of spe-cialized metabolites currently found in plants.Metabolic diversity in the plant kingdom is truly amazing,and although many plant metabolites have already been identified,a large number of potentially useful chemicals remain unexplored in plant bio-resources.Similarly,biosynthetic routes for plant metabolites involve many enzymes,some of which still wait for identification and biochemical charac-terization.Moreover,regulatory mechanisms that control gene expression and enzyme activities in specialized metabolism of plants are scarcely known.Finally,understanding of how plant defense chemicals exert their toxicity and/or repellency against herbivores remains limited to typical exam-ples,such as proteinase inhibitors,cyanogenic compounds and nicotine.In this review,we attempt summarizing the current status quo in metabolic defense of plants that is predominantly based on the survey of ubiquitous examples of plant inter-actions with chewing herbivores.