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目的:探讨儿童2型糖尿病的发生情况及高危因素,为制订防治策略和措施提供科学依据。方法:选择2010年1月～2012年12月2型糖尿病患儿共60例作为研究对象。根据性别、居住地等相近,年龄相差不超过2岁的原则选择60例儿童作为对照组。病例组和对照组均采用相同的方法进行调查问卷、体格检查和实验室检测。所有数据采用SPSS 16.0进行统计分析。结果:病例组BMI、SBP、DBP、FPG和LDL-C分别为(21.94±2.15)kg/m2、(116.18±11.46)mmHg、(76.19±6.18)mmHg、(7.28±0.53)mmol/L和(2.66±0.75)mmol/L,高于对照组的(20.85±2.27)kg/m2、(110.86±10.03)mmHg、(71.36±5.12)mmHg、(4.78±0.50)mmol/L和(2.38±0.72)mmol/L,差异均有统计学意义(P<0.05)。多因素分析结果显示,糖尿病家族史、母亲妊娠期高血糖、肥胖、TG和LDL-C是儿童2型糖尿病的危险因素,HDL-C是保护因素。结论:2型糖尿病儿童应被重视,在制订预防控制策略和措施时应结合儿童其他代谢异常综合考虑。
Objective: To investigate the occurrence and risk factors of type 2 diabetes in children and provide a scientific basis for formulating prevention and control strategies and measures. Methods: A total of 60 children with type 2 diabetes from January 2010 to December 2012 were selected as the study subjects. According to the gender, place of residence and the like, the difference between the age of not more than 2 years old, 60 children were selected as the control group. The same methods were used in the case group and the control group to conduct questionnaires, physical examination and laboratory tests. All data using SPSS 16.0 for statistical analysis. Results The BMI, SBP, DBP, FPG and LDL-C of the patients were (21.94 ± 2.15) mmHg, (116.18 ± 11.46) mmHg, (76.19 ± 6.18) mmHg and (2.66 ± 0.75) mmol / L and (20.85 ± 2.27) kg / m2, (110.86 ± 10.03) mmHg, (71.36 ± 5.12) mmHg and (4.78 ± 0.50) mmol / L and (2.38 ± 0.72) mmol / L, the differences were statistically significant (P <0.05). Multivariate analysis showed that family history of diabetes, hyperglycemia during pregnancy, obesity, TG and LDL-C were risk factors for type 2 diabetes in children, and HDL-C was protective factor. Conclusion: Children with type 2 diabetes mellitus should be taken seriously. When making prevention and control strategies and measures, children with other metabolic disorders should be considered comprehensively.