多年来,对于慢性充血性心力衰竭(C-HF)的药物治疗,仅限于选用地高辛和利尿剂。但对晚期、重度CHF,即使两者联合治疗也未必有效。 CHF的治疗药近5年来已研制出比过去200年来更多的CHF治疗新药。口服药已达80余种,静脉试用者也已超过30种。口服药中有些兼有正性肌力和血管扩张作用,列为“正性肌力-血管扩张药”(Inodilators),如异波帕明(Ibopamine)。 CHF治疗药物的选择利尿药虽能短期缓解症状,但未必都能改善运动耐量,对病死率的影响不明,长程单一治疗无效,且可引起电解质紊乱(特别是低钾血症)。地高辛虽 For many years, medication for chronic congestive heart failure (C-HF) was limited to use of digoxin and diuretics. But for advanced, severe CHF, even if the combination of the two may not be effective. CHF Therapeutics Nearly five years have seen the development of new drugs for the treatment of CHF over the past 200 years. Oral medicine has reached more than 80 species, intravenous trial users have more than 30 species. Some of the oral medications have both inotropic and vasodilating properties listed as “Inodilators” such as Ibopamine. The choice of treatment for CHF Although diuretics can relieve symptoms in the short term, it may not necessarily improve exercise tolerance. The effect on mortality is unknown. Long-term single treatment is ineffective and can cause electrolyte disturbances (especially hypokalemia). Although digoxin